In the high technology industry such as Semiconductor, LCD, PDP & Chemical Industry, the defects are usually occurred in the process, equipments, handling of products and its environment. At a semiconductor fab as an example, those defects affect the yield and the electronic characteristics of devices seriously. The defect cost is currently estimated approximately US$5,000,000,000 a year for yield loss and US$1,000,000,000 a year for the defect management. DefectwareTM, an well known software, consists of the exclusive technology : a 12-step algorithm based on Optimal Reliability Region Design by disparity pair solution, and it is the first technology to analyze the effect of failed chips by defect causing yield loss in semiconductor manufacturing. iSEMICON, Inc. has newly developed new system, iEngineer FDC365, Yield Enhancement solution with Automatic Analysis/Reporting Function providing user the best efficient solution to optimize the manufacturing process and is able to save maximum 20% of the cost of yield loss by defect and defect management.